MP-453088-9 THE SPATIAL VENTRICULAR GRADIENT IS ASSOCIATED WITH CARDIAC MAGNETIC RESONANCE MARKERS OF OF DIFFUSE MYOCARDIAL FIBROSIS

Cardiac MRI (CMR) markers of diffuse myocardial fibrosis are prognostic importance in cardiomyopathies. However, CMR is expensive, time-consuming, and not readily available. An ECG correlate for fibrosis, via its effect on electrical heterogeneity, would be useful. The spatial ventricular gradient (SVG), a vectorcardiographic (VCG) measurement promising detected fibrosis. To assess the relationship SVG to extracellular volume (ECV) native T1 values patients referred CMR. Retrospective cohort study all from 2015 2022 at single academic medical center who had ECG(s) performed within 30 days Median VCGs were constructed 12-lead ECGs, was calculated as area under X, Y, Z median beats. ECV regressed vector magnitude, QT interval, QRS duration using linear regression. compared rank-sum test. We evaluated 679 underwent measurements recent ECG. sample 60% male mean age 55 +/- 16 years. figure shows how magnitude inversely correlated with both (p<0.001 both). In lowest highest quartiles (0.03-0.28 vs 0.35-0.68) (1041-1227 1315-1535 ms), significantly lower: 48.7 32.3 mv*ms ECV, 48.5 multivariable model, remained independently associated after adjustment duration, age, sex (p<0.001). measures Patients higher unlikely have significant burden